宋雪娇 教授，硕士生导师

2012年获苏州大学轻化工程专业学士学位；2017年获苏州大学材料科学与工程专业博士学位；2017年至2018年在澳门大学中华医药研究院从事博士后研究工作。2018年加入十大菠菜网正规平台，被聘为副教授，硕士生导师，2022年晋升为教授。

联系方式：xjsong@njtech.edu.cn

研究领域：高分子材料与生物纳米材料，生物微环境响应递药系统，肿瘤光学成像，肿瘤多模态治疗

主要成果和技术贡献

近年来从材料科学领域出发，结合多学科交叉研究的优势，在纳米生物医学等领域从事科学研究。发展了多种功能纳米材料，实现肿瘤精准治疗，有效提高肿瘤治疗特异性及治疗疗效。

从2012年起以第一/通讯作者在Angew. Chem. Int. Ed.、Adv. Mater.、Nano Today、Nano Lett.、Adv. Funct. Mater.、Small、Biomaterials等材料、化学领域权威期刊发表学术论文40余篇，论文SCI总他引超2000，6篇SCI论文被选为高被引论文。研究成果先后受到Materials Views、Materials Views China和X-MOL等众多媒体和网站的亮点报道。获得国家自然科学基金青年基金、国家自然科学基金重点项目等资助。

招生方向:

本研究方向热忱欢迎有志从事科研工作的本科生、研究生到课题组学习作。欢迎具有化学、材料、或生物医学背景的同学报考。

代表性论文

1. Changyu Cao,# Nan Yang,# Yan Su, Zheye Zhang, Chenxi Wang, Xuejiao Song,* Peng Chen,* Wenjun Wang, Xiaochen Dong*. Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme. Advanced Materials, 2022: 2203236

2. Han Huang , Xiaorui Wang , Weili Wang , Xinyu Qu , Xuejiao Song *, Yewei Zhang , Liping Zhong , Da-peng Yang , Xiaochen Dong *, Yongxiang Zhao *. Injectable hydrogel for postoperative synergistic photothermal-chemodynamic tumor and anti-infection therapy. Biomaterials, 2022, 280: 121289.

3. Changyu Cao, Xiaorui Wang, Nan Yang, Xuejiao Song* and Xiaochen Dong *. Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry[J]. Chemical Science, 2022, 13(4): 863-889.

4. Changyu Cao, Hai Zou, Nan Yang, Hui Li, Yu Cai, Xuejiao Song*, Jinjun Shao, Peng Chen*, Xiaozhou Mou*, Wenjun Wang, Xiaochen Dong*, Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy, Advanced Materials, 2021, 33(44), 2106996-2107006

5. Jiawei Zhu, Weili Wang, Xiaorui Wang, Liping Zhong, Xuejiao Song*, Wenjun Wang, Yongxiang Zhao*, Xiaochen Dong*, Multishell Nanoparticles with “Linkage Mechanism” for Thermal Responsive Photodynamic and Gas Synergistic Therapy, Advanced Healthcare Materials, 2021, 10(10),2002038

6. Zhu, Jiawei: Jiao, Aihong: Li, Qinzhe: Lv, Xinyi: Wang, Xiaorui: Song, Xuejiao*: Li, Buhong*: Zhang, Yewei: Dong, Xiaochen*, Mitochondrial Ca2+-overloading by oxygen/glutathione depletion-boosted photodynamic therapy based on a CaCO3 nanoplatform for tumor synergistic therapy, Acta biomaterialia, 2021;9:4 doi:10.1016/j.actbio.2021.10.016

7. Nan Yang, Tian Zhang, Changyu Cao, Genxiang Mao, Jinjun Shao, Xuejiao Song*, Wenjun Wang, Xiaozhou Mou*, and Xiaochen Dong*, BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy, Nano Research, 2021, 14(9)

8.Changyu Cao, Nan Yang, Ye Zhao, Dapeng Yang, Yanling Hu*, Dongliang Yang, Xuejiao Song*, Wenjun Wang, Xiaochen Dong*, Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy, Nano Today, 2021, 39 101165-101177

9.Jiajia Yin, Xiaorui Wang, Xu Sun, Hanming Dai, Xuejiao Song,* Buhong Li, Yewei Zhang,* Peng Chen, and Xiaochen Dong*, Thrombin Based Photothermal-Responsive Nanoplatform for Tumor-Specific Embolization Therapy, Small, 2021,2105033

10. Jiaojiao Zhang; Han Huang; Lei Xue; Liping Zhong; Wei Ge; Xuejiao Song*; Yongxiang Zhao*; Wenjun Wang; Xiaochen Dong*，On-demand drug release nanoplatform based on fluorinated aza-BODIPY for imaging-guided chemo-phototherapy, Biomaterials, 2020, 256: 120211

11. Qinzhe Li; Yewei Zhang; Xuan Huang; Dongliang Yang*; Lixing Weng; Changjin Ou; Xuejiao Song*; Xiaochen Dong*，An NIR-II light responsive antibacterial gelation for repetitious photothermal/thermodynamic synergistic therapy, Chemical Engineering Journal, 2020, 407: 127200

12. Yunhao Shi; Jiaojiao Zhang#; Han Huang; Changyu Cao; Jiajia Yin; Wenjing Xu; Wenjun Wang; Xuejiao Song*; Yewei Zhang*; Xiaochen Dong*, Fe-Doped Polyoxometalate as Acid-Aggregated Nanoplatform for NIR-II Photothermal-Enhanced Chemodynamic Therapy, Advanced Healthcare Materials, 2020, 9: 2000005

13. Shichao Zhang; Changyu Cao; Xinyi Lv; Hanming Dai; Zhihao Zhong; Chen Liang; Wenjun Wang; Wei Huang; Xuejiao Song*; Xiaochen Dong*, A H2O2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy, Chemical Science, 2020, 11: 1926

14. NanYang; Wanyue Xiao; Xuejiao Song*; Wenjun Wang; Xiaochen Dong*, Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy, NANO-MICRO LETTERS, 2020, 12

15. Gongyuan Liu, Jiawei Zhu, Heng Guo, Aihui Sun, Peng Chen*, Lei Xi*, Wei Huang, Xuejiao Song*, Xiaochen Dong*; “Mo2C‐Derived Polyoxometalate for NIR‐II Photoacoustic Imaging‐Guided Chemodynamic/Photothermal Synergistic Therapy”; Angewandte Chemie International Edition; 58(51); 18641-18646; 2019;

16. Shichao Zhang, Qinzhe Li, Nan Yang, Yunhao Shi, Wei Ge, Wenjun Wang, Wei Huang, Xuejiao Song*, Xiaochen Dong*; “Phase-Change Materials Based Nanoparticles for Controlled Hypoxia Modulation and Enhanced Phototherapy”; Advanced Functional Materials; 29(49); 1906805; 2019;

17. Peng Wang, Chen Liang, Jiawei Zhu, Nan Yang, Aihong Jiao*, Wenjun Wang, Xuejiao Song*, Xiaochen Dong*; “Manganese-Based Nanoplatform As Metal Ion-Enhanced ROS Generator for Combined Chemodynamic/Photodynamic Therapy”; ACS Applied Materials & Interfaces; 11(44); 41140-41147; 2019;

18. Qianyun Tang, Zijin Cheng, Nan Yang, Qinzhe Li, Peng Wang, Dapeng Chen, Wenjun Wang, Xuejiao Song*, Xiaochen Dong*; “Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy”; Biomaterials; 205;1-10;2019;

19. Xiaoyan Yang, Dongya Wang, Jiawei Zhu, Lei Xue, Changjin Ou, Wenjun Wang, Min Lu*, Xuejiao Song*, Xiaochen Dong*; “Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy”; Chemical Science; 10, 3779-3785, 2019;

20. Xuejiao Song, Jun Xu, Chao Liang, Yu Chao, Qiutong Jin, Chao Wang, Meiwan Chen, Zhuang Liu*; “Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer”; Nano Letters; 18, 6360−6368; 2018;

21. Xuejiao Song, Liangzhu Feng, Chao Liang, Kai Yang, and Zhuang Liu*; “Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies”; Nano Letters; 16(10); 6145-6153; 2016;